Bis-sulfonomides hydroxamic acids as matrix metalloproteinase (MMP) inhibitors

The present invention provides a compound of formula I I or pharmaceutically acceptable salts thereof wherein R1 and R2 are the same or different and are C1-10 alkyl, phenyl, hetero-aryl, or phenyl substituted with C1-4 alkyl, OR3, NHR3, CONHR3, NHCOR3, or halo; wherein R3 is H, or C1-4 alkyl; and n...

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Bibliographische Detailangaben
Hauptverfasser:	SKALETZKY, LOUIS L, JACOBSEN, ERIC JON
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides a compound of formula I I or pharmaceutically acceptable salts thereof wherein R1 and R2 are the same or different and are C1-10 alkyl, phenyl, hetero-aryl, or phenyl substituted with C1-4 alkyl, OR3, NHR3, CONHR3, NHCOR3, or halo; wherein R3 is H, or C1-4 alkyl; and n is 1, 2, 3, 4, 5, or 6. The compounds are inhibitors of matrix metalloproteinases involved in tissue degradation.