Compact member comprising a plurality of porous cellulose matrices (PCMs)

The specification describes a compact member comprising a plurality of porous cellulose matrices (PCMs) which provide an extended release of an active compound located in the pores of PCMs together with a release-modifying agent. The friability of the compact member is less than 2.1% by weight, and...

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Bibliographische Detailangaben
Hauptverfasser: GREN, TORKEL, NYSTROM, CHRISTER
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The specification describes a compact member comprising a plurality of porous cellulose matrices (PCMs) which provide an extended release of an active compound located in the pores of PCMs together with a release-modifying agent. The friability of the compact member is less than 2.1% by weight, and the disintegration time in vitro of the compact member is less than 240 minutes. The compact member is manufactured by exposing a plurality of PCMs to an active compound and a release-modifying agent, in optional sequence or mixture, for a time sufficient for said active compound and release-modifying agent to fill the pores in said PCMs to a preselected level. The PCMs are subsequently compacted to a desired shape.