Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors and their use and manufacture as medicaments

Inhibitors for matrix metalloproteases, pharmaceutical compositions containing them, the method for their manufacture and a process for using them to treat a variety of physiological conditions. The compounds of the invention have generalized formula (I) wherein: T is a pharmaceutically acceptable substituent group; x is 0, 1 or 2 m is 0 or an integer of 1-4 n is 0 or 1 A is CH2, CH, or N; G is CH2 or CH; R1 is any of a variety of disclosed substituent groups. The class of compounds of the invention includes ring-containing materials in which the units A and G are joined. The compounds of the invention are mixtures of diastereomers, or individual diastereomers making up these mixtures. Also disclosed is the use of the above compound as a medicament for treating matrix metalloprotease-mediated condition such as osteoarthritis, rheumatoid arthritis, septic arthritis, periodontal disease, corneal ulceration, proteinuria and other associated diseases.