Use of dialkyl ether derivatives in treatment of diseases

A method of lowering plasma Lp (a) by administration to non-human mammals an Lp(a) lowering amount of a compound of the formula (I) wherein n and m independently are integers from 2 to 9; R1, R2, R3, and R4 independently are Cl-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, and R1 and R2 together with the...

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Hauptverfasser: SALTIEL, ALAN ROBERT, CREGER, PAUL LEROY, TAFURI, SHERRIE RAE, BISGAIER, CHARLES LARRY
Format: Patent
Sprache:eng
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Zusammenfassung:A method of lowering plasma Lp (a) by administration to non-human mammals an Lp(a) lowering amount of a compound of the formula (I) wherein n and m independently are integers from 2 to 9; R1, R2, R3, and R4 independently are Cl-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, and R1 and R2 together with the carbon to which they are attached, and R3 and R4 together with the carbon to which they are attached, independently can complete a carbocyclic ring having from 3 to 6 carbons; Yl and Y2 independently are COOH, CHO, tetrazole, and COOR5 where R5 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl; and where the alkyl, alkenyl, and alkynyl groups may be substituted with one or two groups selected from halo, hydroxy, C1-C6 alkoxy, and phenyl, and the pharmaceutically acceptable salts thereof. (62) Divided Out of 302170