Process for the preparation of 17-esters of 9alpha,21-dihalo-pregnane-11beta,17alphadiol-20-ones

Process for the preparation of 17-esters of 9alpha,21-dihalo-pregnane-11beta,17alphadiol-20-ones

The application provides a process for the preparation of 17-esters of 9a,21-dihalo-pregnane-11b,17a-diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids of Figure I, where COR is a carboxylic acid group, R1 is H or lower alkyl, X and Y each are F, Cl or Br...

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Bibliographische Detailangaben
Hauptverfasser: KWOK, DAW-IONG ALBERT, TSAI, DAVID J S, TANN, CHOU-HONG, FU, XIAOYONG
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
STEROIDS
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Beschreibung
Zusammenfassung:The application provides a process for the preparation of 17-esters of 9a,21-dihalo-pregnane-11b,17a-diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids of Figure I, where COR is a carboxylic acid group, R1 is H or lower alkyl, X and Y each are F, Cl or Br and the dotted line indicates a single or double bond. The process is especially suitable for the preparation of Mometasone Furoate.