Compositions comprising a nitrone compound for use in treating ocular inflammation

An ophthalmic pharmaceutical composition for treating ocular inflammation, such as uveitis, comprising 5,5-dimethylpyrroline-N-oxide or a compound of formula I: wherein each R1 is independently selected from the group consisting of alkyl, lower alkoxy, aminoacyl, acyloxy, hydroxy and -COtY, wherein...

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Bibliographische Detailangaben
Hauptverfasser:	CARNEY, JOHN MICHAEL, DUZMAN, EFRAIM, NARDUCY, KENNETH W, WILCOX, ALLAN LEE
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	An ophthalmic pharmaceutical composition for treating ocular inflammation, such as uveitis, comprising 5,5-dimethylpyrroline-N-oxide or a compound of formula I: wherein each R1 is independently selected from the group consisting of alkyl, lower alkoxy, aminoacyl, acyloxy, hydroxy and -COtY, wherein Y is hydrogen or a pharmaceutically acceptable salt; R2 is selected from the group consisting of hydrogen, alkyl and aryl; R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, allcaryi, alkcycloalkyl, cycloalkyl and cycloalkenyl; X is CH or N~O; and n is an integer from 0 to 3.