Anticoagulant agents useful in treatment of thrombosis

n anti-factor IX monoclonal antibody having self-limiting neutralizing activity against Factor IX and the identifying characteristics of SB 249413, SB 249415, SB 249417, SB 257731 or SB 257732 is claimed. Also claimed are an immunoglobulin heavy chain complementary determining region having an amino...

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Bibliographische Detailangaben
Hauptverfasser:	FEUERSTEIN, GIORA ZEEV, PATEL, ARUNBHAI HARIBHAI, GROSS, MITCHELL STUART, PADLAN, EDUARDO AGUSTIN, SYLVESTER, DANIEL ROBERT, BLACKBURN, MICHAEL NEAL, CHURCH, WILLIAM ROBERT, NICHOLS, ANDREW JOHN
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	n anti-factor IX monoclonal antibody having self-limiting neutralizing activity against Factor IX and the identifying characteristics of SB 249413, SB 249415, SB 249417, SB 257731 or SB 257732 is claimed. Also claimed are an immunoglobulin heavy chain complementary determining region having an amino acid sequence selected from SEQ. ID NO 8, 9 and 10 as defined in the specification and the nucleic acid molecule encoding it. Also claimed are an immunoglobulin light chain complementary determining region having an amino acid sequence selected from SEQ. ID NO 12, 13 and 14 as defined in the specification and the nucleic acid molecule encoding it. Divisional filed as 501215