Bis-triazine derivatives and pharmaceutical compositions thereof, useful in the treatment of viral infections

A compound has the formula I: A is a moiety of formula II, III, IV, V, VI, or VII -C' is -SO3H, -OSO3H, -OH, or -COOH; B' is -NH, NR1, or O, where -R1 is H, or (C1-C6)alkyl (where (C1-C6)alkyl may be substituted with Cl, Br, F, OH, or CN); X is Cl, F, or a moiety of formula VIII; U' i...

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Hauptverfasser: ELLESTAD, GEORGE ALFRED, RAIFELD, YURI EFIMOVICH, DING, WEI-DONG, MITSNER, BORIS, NIKITENKO, ANTONINA ARISTOTELEVNA, O'HARA, BRYAN MARK, LAROCQUE, JAMES PAUL, MORIN, JOHN EDWARD, GLUZMAN, YAKOV
Format: Patent
Sprache:eng
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Zusammenfassung:A compound has the formula I: A is a moiety of formula II, III, IV, V, VI, or VII -C' is -SO3H, -OSO3H, -OH, or -COOH; B' is -NH, NR1, or O, where -R1 is H, or (C1-C6)alkyl (where (C1-C6)alkyl may be substituted with Cl, Br, F, OH, or CN); X is Cl, F, or a moiety of formula VIII; U' is -SO2, -CO, -NC(O), or -NC(S); W' is a moiety of formula IX, X, or XI, where -Y is -(CH2)n-; -n is 0 to 6 -m is 0 to 2 -Z is H, CH3, CF3, -CH2-(halogen), -CH2OH, -COOH, -COO(C1-C6)alkyl, -CONR2R2 or CN (where R2 is H or (C1-C6)alkyl; or a pharmaceutically acceptable salt thereof. A pharmaceutical composition comprises a compound of formula I (or a pharmaceutically acceptable salt thereof), and at least one carrier. A use in the manufacture of a medicament for treating viral infection in a mammal, of a compound of formula I. Addition to 328399