1-omega-(3,4-dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives and their use

isclosed are 1-[w-(3,4-Dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives represented by general formula (I) and salts and N-oxide derivatives thereof, wherein R1 and R2 represent each hydrogen, halogeno, hydroxy, alkyl, alkoxy, hydroxymethyl, etc., or R1 and R2 form together methylenedioxy, tri...

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Hauptverfasser: SHIMUZU, ISAO, AKIYAMA, KAZUHISA, KAWASHIMA, KATSUYOSHI, KAI, NAOKI, HINO, KATSUHIKO, KANEHIRA, AKI, MORIE, TOSHIYA
Format: Patent
Sprache:eng
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Zusammenfassung:isclosed are 1-[w-(3,4-Dihydro-2-naphthalenyl)alkyl] cyclic amine derivatives represented by general formula (I) and salts and N-oxide derivatives thereof, wherein R1 and R2 represent each hydrogen, halogeno, hydroxy, alkyl, alkoxy, hydroxymethyl, etc., or R1 and R2 form together methylenedioxy, trimethylene, etc.; R3 represents hydrogen, etc.; R4 represents hydrogen, hydroxy, alkyl, etc.; R5 represents hydrogen, alkyl, etc.; p is an integer of from 2 to 6; and q is an integer of from 3 to 7; excluding the case where R1, R2, R3, R4 and R5 are all hydrogen, p is 2 and q is 5. The compounds have a potent effect of suppressing urinary reflex and thus are useful as a remedy for frequent urination and urinary incontinence.