PROCESS FOR PREPARING 1-(HET)ARYL-3-HYDROXYPYRAZOLES FROM PROPIOLIC ACID ESTERS AND (HET)ARYLHYDRAZINES

PROCESS FOR PREPARING 1-(HET)ARYL-3-HYDROXYPYRAZOLES FROM PROPIOLIC ACID ESTERS AND (HET)ARYLHYDRAZINES

The prepn. of 1-(Hetero)aryl-3-hydroxy-pyrazoles of formula (I) comprises mixing propiolic acid esters of formula R1C IDENTICAL CCOOR' (II) with (hetero)arylhydrazine derivs. of formula RNHNH2 (III) in an inert solvent; and then treating with a base at 0-60 degrees C. R = opt. substd. aromatic...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: OBERDORF, KLAUS, GOTZ, NORBERT, MULLER, BERND, KIRSTGEN, REINHARD, KONIG, HARTMANN
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The prepn. of 1-(Hetero)aryl-3-hydroxy-pyrazoles of formula (I) comprises mixing propiolic acid esters of formula R1C IDENTICAL CCOOR' (II) with (hetero)arylhydrazine derivs. of formula RNHNH2 (III) in an inert solvent; and then treating with a base at 0-60 degrees C. R = opt. substd. aromatic or heteroaromatic; n = 0, 1 or 2; R1 = a gp. which is stable under the reaction conditions; R' = alkyl, cycloalkyl or aryl.