THE PREPARATION OF 3-CYANO-4-AMINOACETOPHENONES AND THEIR USE AS INTERMEDIATES IN PREPARING 2-AMINO-5-(1-HYDROXY-2-(ALKYL- OR DIALKYL-AMINO)ETHYL) BENZONITRILES

THE PREPARATION OF 3-CYANO-4-AMINOACETOPHENONES AND THEIR USE AS INTERMEDIATES IN PREPARING 2-AMINO-5-(1-HYDROXY-2-(ALKYL- OR DIALKYL-AMINO)ETHYL) BENZONITRILES

1. Process for preparing 3-cyano-4-amino-acetophenones of general formula see diagramm : EP0158932,P4,F1 wherein R represents a hydrogen or fluorine atom, characterized in that a 3-cyano-4-acetamino-acetophenone of general formula see diagramm : EP0158932,P4,F2 wherein R is defined as hereinbefore,...

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Bibliographische Detailangaben
Hauptverfasser: FRAUNBERGER, F, RESEMANN, W
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:1. Process for preparing 3-cyano-4-amino-acetophenones of general formula see diagramm : EP0158932,P4,F1 wherein R represents a hydrogen or fluorine atom, characterized in that a 3-cyano-4-acetamino-acetophenone of general formula see diagramm : EP0158932,P4,F2 wherein R is defined as hereinbefore, is saponified with potassium hydroxide, sodium hydroxide, potassium or sodium methoxide in the presence of methanol as solvent at temperatures up to the boiling point of the reaction mixture and the compound of general formula I is isolated from the reaction mixture.