1,2,3-TRIHYDRO-3-(1H-IMIDAZOL-1-YLMETHYL)-4H-CARBAZOL-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

1,2,3-TRIHYDRO-3-(1H-IMIDAZOL-1-YLMETHYL)-4H-CARBAZOL-4-ONE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS

Compounds of formula (I). [wherein R is hydrogen C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl, and one of the groups represented by R , R and R is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl and each of the other two groups, which may be the same...

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Bibliographische Detailangaben
Hauptverfasser: HUMBER, D C, COATES, I H, EWAN, G B, BELL, J A
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Compounds of formula (I). [wherein R is hydrogen C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl, and one of the groups represented by R , R and R is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl and each of the other two groups, which may be the same or different, is hydrogen or C1-6alkyl; and physiologically acceptable salts and solvates, e.g. hydrates, thereof] are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.