1,2,3,4-TETRAHYDRO-2-NAPHTHYLAMINE DERIVATIVES

1,2,3,4-TETRAHYDRO-2-NAPHTHYLAMINE DERIVATIVES

Compounds of the formula I wherein R3 and the NR1R2 group are in a cis-position to each other and wherein Y is OH, R4COO, (R5)2NCOO or R6O either in position 5 or position 7, whereby R4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R5 is an alkyl group having 1-5...

Ausführliche Beschreibung

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Hauptverfasser: LINDBERG, P.L, JOHANSSON, A.M, CARLSSON, P.A.E, SANCHEZ, D, HJORT, J.S.M, WIKSTROM, H.V, HACKSELL, U.A, ARVIDSSON, F.L-E, NILSSON, J.L.G
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Compounds of the formula I wherein R3 and the NR1R2 group are in a cis-position to each other and wherein Y is OH, R4COO, (R5)2NCOO or R6O either in position 5 or position 7, whereby R4 is an alkyl group having 1-5 carbon atoms or a possibly substituted phenyl group, R5 is an alkyl group having 1-5 carbon atoms and R6 is an allyl or benzyl group, R1 is hydrogen or an alkyl group having 1-3 carbon atoms, R2 is an alkyl group having 1-6 carbon atoms, a phenylalkyl- or m-hydroxyphenylalkyl group with 2-4 carbon atoms in the alkyl part, or an alkenyl group with 3-6 carbon atoms other than 1-alkenyl, and R3 is an alkyl group having 1-3 carbon atoms, processes and intermediates for their preparation, pharmaceutical preparations and methods of treatment employing such compounds. The compounds are useful for therapeutic purposes, especially for treatment of disorders in the central nervous system.