SHORT CHAIN PEPTIDES WHICH INCREASE IMMUNOLOGICAL COMPETENCE

SHORT CHAIN PEPTIDES WHICH INCREASE IMMUNOLOGICAL COMPETENCE

Novel peptides of the formula:wherein:A, A' and A" are each independently Gly, D-Ala, D-Leu, or D-Trp, wherein A may optionally be N-alkylated or N-acylated;B is Pro, Δ3-Pro, Thz, or diMeThz;C and C' are each independently Thr, Ser, Val, or alloThr;D is Glu, Gln, Asp, or Asn;R is hydr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BURTON, P.M, JONES, G.H, WHITE, A, NESTOR, J.J
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Novel peptides of the formula:wherein:A, A' and A" are each independently Gly, D-Ala, D-Leu, or D-Trp, wherein A may optionally be N-alkylated or N-acylated;B is Pro, Δ3-Pro, Thz, or diMeThz;C and C' are each independently Thr, Ser, Val, or alloThr;D is Glu, Gln, Asp, or Asn;R is hydrogen, or is lower alkyl or lower acyl, substituted for one of the hydrogens on the ε-amino group of the lysyl residue;X is Cys, Ala, ABU, or Cys(Me); andY is selected from hydroxy, Pro, Pro-Leu, and Pro-Leu-Met, -NH2, ProNH2, Pro-LeuNH2 and Pro-leu-MetNH2;and the pharmaceutically acceptable salts thereof, are useful for increasing immunologic competence. Methods for preparation of the peptides are also described.