DERIVATIVES OF C-076 COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS

Derivatives of C-076 compounds of formulae 1,2 and 3, isolated from the fermentation broth of S.avermilitis ATCC 31267, 31271 and 31272, that produced the original C-076 compounds, retaining the biological activity of the parent compounds, e.g. as antiparasitic agents, wherein R1 is -OH and R2 is se...

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Hauptverfasser: ARISON, B. H, GOEGELMAN, R. T, GULLO, V. P
Format: Patent
Sprache:eng
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Zusammenfassung:Derivatives of C-076 compounds of formulae 1,2 and 3, isolated from the fermentation broth of S.avermilitis ATCC 31267, 31271 and 31272, that produced the original C-076 compounds, retaining the biological activity of the parent compounds, e.g. as antiparasitic agents, wherein R1 is -OH and R2 is sec-butyl; )b) R1 is = O and R2 is sec-butyl. wherein R3 is hydrogen or hydroxyl;