En kontrollert frigjoerende formulering for tungt loeselige basiske legemidler

En kontrollert frigjoerende formulering for tungt loeselige basiske legemidler

Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to f...

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Hauptverfasser: FEELY, LIAM C, WITHERS, BRIAN C, BROAD, NEVILLE W, CARMODY, ALAN F
Format: Patent
Sprache:nor
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HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator FEELY, LIAM C
WITHERS, BRIAN C
BROAD, NEVILLE W
CARMODY, ALAN F
description Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to facilitate dissolution of the basic drug. An Independent claim is also included for a controlled release solid pharmaceutical composition (I) adapted for oral administration of a once-a-day dosage regimen and comprising (in mg): clarithromycin (500), sodium-calcium alginate (75-400) and citric acid (128).
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subjects HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title En kontrollert frigjoerende formulering for tungt loeselige basiske legemidler
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