En kontrollert frigjoerende formulering for tungt loeselige basiske legemidler

Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to f...

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Bibliographische Detailangaben
Hauptverfasser:	FEELY, LIAM C, WITHERS, BRIAN C, BROAD, NEVILLE W, CARMODY, ALAN F
Format:	Patent
Sprache:	nor
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Controlled-release, solid, pharmaceutical compositions adapted for oral administration comprises: (a) at least one basic drug with a water solubility of less than 1 part per 30 parts water; (b) a water-soluble alginate salt; (c) a complex salt of alginic acid; and (d) an organic carboxylic acid to facilitate dissolution of the basic drug. An Independent claim is also included for a controlled release solid pharmaceutical composition (I) adapted for oral administration of a once-a-day dosage regimen and comprising (in mg): clarithromycin (500), sodium-calcium alginate (75-400) and citric acid (128).