Fremgangsmåte for fremstilling av 2-£2-£4-£4-klorfenyl)fenylmetyl|-1-piperazinyl|etoksy|eddiksyre og dens salter

Fremgangsmåte for fremstilling av 2-£2-£4-£4-klorfenyl)fenylmetyl|-1-piperazinyl|etoksy|eddiksyre og dens salter

Preparation of cetirizine (2-Ä2-Ä4-Ä(4-chlorophenyl)phenylmethylÜ-1-piperazinylÜethoxyÜacetic acid) (I) comprises reacting 1-Ä(4-chlorophenyl)phenylmethylÜ-piperazine (II) with 2-chloroethoxyacetic acid in the presence of an acid acceptor and in an inert solvent. Acid acceptors are preferably select...

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Bibliographische Detailangaben
Hauptverfasser: DUCHENE, GUY, ZIMMERMANN, VINCENT, BODSON, GUY
Format: Patent
Sprache:nor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Preparation of cetirizine (2-Ä2-Ä4-Ä(4-chlorophenyl)phenylmethylÜ-1-piperazinylÜethoxyÜacetic acid) (I) comprises reacting 1-Ä(4-chlorophenyl)phenylmethylÜ-piperazine (II) with 2-chloroethoxyacetic acid in the presence of an acid acceptor and in an inert solvent. Acid acceptors are preferably selected from alkali metal carbonates and hydroxides, triethylamine, ethyl diisopropylamine, N-ethylmorpholine and 2,4,6-trimethyl-pyridine. The molar ratio of (I):(II) is 3:1-1:3 and an alkali metal iodide may also be present.