Benzodiazpinderivater
Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. h...
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| creator | MIYATA, KEIJI SEMPLE, GRAEME SATOH, MASATO OHTA, MITSUAKI SZELKE, MICHAEL NISHIDA, AKITO |
| description | Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. hvori: (a) R4 er en alkyl, cykloalkyl eller arylgruppe. (b) R10 er valgt fra halogen, OH, CH3, OCH3, NRUR12, N02) NHCHO, C02H og CN, og R1' og R12 uavhengig er valgt fra H og alkyl (C,-C5) eller NRUR12 sammen danner en cyklisk struktur II, (CH2). -N hvori a er 1-6; og
PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists. |
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PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.</description><edition>6</edition><language>nor</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1996</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960425&DB=EPODOC&CC=NO&NR=960747L$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19960425&DB=EPODOC&CC=NO&NR=960747L$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MIYATA, KEIJI</creatorcontrib><creatorcontrib>SEMPLE, GRAEME</creatorcontrib><creatorcontrib>SATOH, MASATO</creatorcontrib><creatorcontrib>OHTA, MITSUAKI</creatorcontrib><creatorcontrib>SZELKE, MICHAEL</creatorcontrib><creatorcontrib>NISHIDA, AKITO</creatorcontrib><title>Benzodiazpinderivater</title><description>Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. hvori: (a) R4 er en alkyl, cykloalkyl eller arylgruppe. (b) R10 er valgt fra halogen, OH, CH3, OCH3, NRUR12, N02) NHCHO, C02H og CN, og R1' og R12 uavhengig er valgt fra H og alkyl (C,-C5) eller NRUR12 sammen danner en cyklisk struktur II, (CH2). -N hvori a er 1-6; og
PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1996</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBB1Ss2ryk_JTKwqyMxLSS3KLEssSS3iYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxfv6WZgbmJuY-PsaEVQAANqQhUw</recordid><startdate>19960425</startdate><enddate>19960425</enddate><creator>MIYATA, KEIJI</creator><creator>SEMPLE, GRAEME</creator><creator>SATOH, MASATO</creator><creator>OHTA, MITSUAKI</creator><creator>SZELKE, MICHAEL</creator><creator>NISHIDA, AKITO</creator><scope>EVB</scope></search><sort><creationdate>19960425</creationdate><title>Benzodiazpinderivater</title><author>MIYATA, KEIJI ; SEMPLE, GRAEME ; SATOH, MASATO ; OHTA, MITSUAKI ; SZELKE, MICHAEL ; NISHIDA, AKITO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_NO960747LL3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>nor</language><creationdate>1996</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MIYATA, KEIJI</creatorcontrib><creatorcontrib>SEMPLE, GRAEME</creatorcontrib><creatorcontrib>SATOH, MASATO</creatorcontrib><creatorcontrib>OHTA, MITSUAKI</creatorcontrib><creatorcontrib>SZELKE, MICHAEL</creatorcontrib><creatorcontrib>NISHIDA, AKITO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MIYATA, KEIJI</au><au>SEMPLE, GRAEME</au><au>SATOH, MASATO</au><au>OHTA, MITSUAKI</au><au>SZELKE, MICHAEL</au><au>NISHIDA, AKITO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Benzodiazpinderivater</title><date>1996-04-25</date><risdate>1996</risdate><abstract>Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. hvori: (a) R4 er en alkyl, cykloalkyl eller arylgruppe. (b) R10 er valgt fra halogen, OH, CH3, OCH3, NRUR12, N02) NHCHO, C02H og CN, og R1' og R12 uavhengig er valgt fra H og alkyl (C,-C5) eller NRUR12 sammen danner en cyklisk struktur II, (CH2). -N hvori a er 1-6; og
PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Benzodiazpinderivater |
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