Benzodiazpinderivater

Benzodiazepinderivat med formel I, eller et farmasøytisk akseptabelt salt derav; (c) R2 er en aromatisk 5- eller 6-leddet, substitu- ert eller usbustituert heterocyklus innehol- dende minst to heteroatomer hvorav minst ett er nitrogen. Forbindelsene er gastrin og/eller CCK-B- reseptorantagonister. hvori: (a) R4 er en alkyl, cykloalkyl eller arylgruppe. (b) R10 er valgt fra halogen, OH, CH3, OCH3, NRUR12, N02) NHCHO, C02H og CN, og R1' og R12 uavhengig er valgt fra H og alkyl (C,-C5) eller NRUR12 sammen danner en cyklisk struktur II, (CH2). -N hvori a er 1-6; og PCT No. PCT/GB94/01859 Sec. 371 Date May 2, 1996 Sec. 102(e) Date May 2, 1996 PCT Filed Aug. 25, 1994 PCT Pub. No. WO95/06040 PCT Pub. Date Mar. 2, 1995A benzodiazepine derivative of formula I, or a pharmaceutically acceptable salt thereof: I wherein: (a) R4 is an alkyl, cycloalkyl or aryl group. (b) R10 is chosen from halo, OH, CH3, OCH3, NR11R12, NO2, NHCHO, CO2H and CN, and R11 and R12 are independently selected from H and alkyl (C1-C5) or together NR11R12 form a cyclic structure II, II wherein a is 1-6; and (c) R2 is an aromatic 5- or 6-membered, substituted or unsubstituted heterocycle containing at least two heteroatoms of which at least one is nitrogen. These compounds are gastrin and/or CCK-B receptor antagonists.