Hepatitt B-escapemutantspesifikke bindingsmolekyler

Molekyler som spesifikt kan bindes til en antigen determinant hos en hepa- titt B-"escape"-mutant omfatter mono- klonale antistoffer som utskilles av cellelinjen SMH HBs 145/G/R/I (ECACC 92122312), SMH HBs 145/R/I (ECACC 93052626), SMH HBs 145/G/R/II (ECACC 93033109) eller SMH HBs 145/R/II...

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Bibliographische Detailangaben
Hauptverfasser:	WATERS, JENNIFER ANNE, THOMAS, HOWARD CHRISTOPHER, CARMAN, WILLIAM FREDERICK
Format:	Patent
Sprache:	nor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Molekyler som spesifikt kan bindes til en antigen determinant hos en hepa- titt B-"escape"-mutant omfatter mono- klonale antistoffer som utskilles av cellelinjen SMH HBs 145/G/R/I (ECACC 92122312), SMH HBs 145/R/I (ECACC 93052626), SMH HBs 145/G/R/II (ECACC 93033109) eller SMH HBs 145/R/II (ECACC 93033110) og andre spesifikt bindende molekyler som krysskonkurrerer med disse. Antistoffer som utskilles av cellelinjene SMH HBs 145/G/R/I og SMH HBs 145/G/R/II, bindes til variant ("escape"-mutant) HBsAg og villtype- HBsAg. Antistoffer som utskilles av cellelinjene SMH HBs 145/R/I og SMH HBs 145/R/II, bindes til variant, men ikke villtype. Molecules which are capable of specifically binding to a hepatitis B escape mutant antigenic determinant include monoclonal antibodies secreted by the cell line SMH HBs 145/G/R/I (ECACC 92122312), SMH HBs 145/R/I (ECACC 93052626), SMH HBs 145/G/R/II (ECACC 93033109) or SMH HBs 145/R/II (ECACC 93033110) and other specific binding molecules cross-competitive with them. Antibodies secreted by the cell lines SMH HBs 145/G/R/I and SMH HBs 145/G/R/II bind variant (escape mutant) HBsAG and wild type HBsAG. Antibodies secreted by the cell lines SMH HBs 145/R/I and SMH HBs 145/R/II bind variant but not wild type.