Fremgangsmåte for fremstilling av kreftvaksiner

Kreftvaksine oppnås ved behandling av tumorceller eller fibroblaster med et kompleks av DNA som koder for et immun- stimulerende polypeptid, og en DNA-bindende substans, f.eks. polylysin, som fortrinnsvis er konjugert med transferrin. Komplekset inneholder videre et konjugat av DNA-bindende substans...

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Bibliographische Detailangaben
Hauptverfasser:	COTTEN, MATTHEW, WAGNER, ERNST, ZATLOUKAL, KURT, MAASS, GERHARD, BIRNSTIEL, MAX L, BUSCHLE, MICHAEL, SCHMIDT, WALTER, PLANK, CHRISTIAN, SCHAFFNER, GOTTHOLD
Format:	Patent
Sprache:	nor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Kreftvaksine oppnås ved behandling av tumorceller eller fibroblaster med et kompleks av DNA som koder for et immun- stimulerende polypeptid, og en DNA-bindende substans, f.eks. polylysin, som fortrinnsvis er konjugert med transferrin. Komplekset inneholder videre et konjugat av DNA-bindende substans og et til dette ionisk bundet endosomolytisk peptid eller et adenovirus, som oppviser i det minste en E4-defekt. Cancer vaccines are prepared by treating tumor cells or fibroblasts with a complex of immunostimulating polypeptide-coding DNA and of DNA-binding substance, for example polylysine, preferably conjugated with transferrine. The complex further contains a conjugate of DNA-binding substance and of an endosomolytic peptide or an adenovirus having at least one E4 defect or one E1a defect associated with other genetic defects.