Anvendelse av 1,4-dihydropyridin-3,5-dikarboksylsyreestere som legemidler

Anvendelse av 1,4-dihydropyridin-3,5-dikarboksylsyreestere som legemidler

Use of 1,4-dihyropyridine-3,5-dicarboxylic acid derivs. of formula (I) as medicaments with a selective modulating effect on high-conductivity Ca-dependent K channels is new: A = 6-10C aryl or pyridyl, opt. substd. by 1-3 of NO2, CN, halogen CF3 and/or 1-6C alkylthio; R1, R2 = 3-6C cycloalkyl, or 1-8...

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Hauptverfasser: JUNGE, BODO, SOMMERMEYER, HENNING, URBAHNS, KLAUS, HEINE, HANS-GEORG, WITTKA, REILINDE, GLASER, THOMAS, GOLDMANN, SIEGFRIED, SCHONE-LOOP, RUDOLF, WOLLWEBER, HARTMUND, VRY, JEAN-MARIE-VIKTOR DE, BEHNER, OTTO, WEHINGER, EGBERT
Format: Patent
Sprache:nor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Use of 1,4-dihyropyridine-3,5-dicarboxylic acid derivs. of formula (I) as medicaments with a selective modulating effect on high-conductivity Ca-dependent K channels is new: A = 6-10C aryl or pyridyl, opt. substd. by 1-3 of NO2, CN, halogen CF3 and/or 1-6C alkylthio; R1, R2 = 3-6C cycloalkyl, or 1-8C alkyl opt. substd. by 1-2 of 1-4C alkoxy, halogen and/or NR4R5; R4, R5 = H, benzyl, phenyl or 1-4C alkyl; R3 = 3-6C cycloalkyl, or 1-6C alkyl opt. substd. by OH, phenyl, 1-6C alkoxy or 2-6C alkoxycarbonyl. Also claimed are 18 cpds. (I).