Analysesystemer for neurotrofinaktivitet

Analysesystemer som kan bli anvendt for å detektere og/eller måle neurotrofinaktiviteten eller identifisere midler som utviser neurotrofin-lignende aktivitet er beskrevet. Den er basert på oppdagelsen av at trkB proto-onkogenet koder for en tyrosinklnasereseptor som kan virke som et funksjonelt bind...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	DISTEPHANO, PETER, SQUINTO, STEPHEN P, MAISON-PIERRE, PETER C, MAISIAKOWSKI, PIOTR, YANCOPOULOS, GEORGE D, GLASS, DAVID, STITT, TREVOR, IP, NANCY, FURTH, MARK E, ALDRICH, THOMAS H
Format:	Patent
Sprache:	nor
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPIRITS TESTING TRAPPING VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Analysesystemer som kan bli anvendt for å detektere og/eller måle neurotrofinaktiviteten eller identifisere midler som utviser neurotrofin-lignende aktivitet er beskrevet. Den er basert på oppdagelsen av at trkB proto-onkogenet koder for en tyrosinklnasereseptor som kan virke som et funksjonelt bindingsprotein for BDNF og NT-3. Diagnostiske og terapeutiske metoder basert på interaksjonen mellom BDNF og/eller NT-3 og trkB samt et antall reseptormolekyler er beskrevet. The present invention provides for assay systems that may be used to detect and/or measure neurotrophin activity or to identify agents that exhibit neurotrophin-like activity. It is based, at least in part, on the discovery that the trkB proto-oncogene encodes a tyrosine kinase receptor that may serve as a functional binding protein for BDNF and NT-3. The present invention also provides for diagnostic and therapeutic methods based on the interaction between BDNF and/or NT-3 and trkB, and for a number of orphan receptor molecules.