ANTICHOLINFORBINDELSER, FARMASTISKE BLANDINGER OG BEHAND LINGSMETODE

Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COO...

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Hauptverfasser:	HAMMER, RICHARD H, BODER, NICHOLAS S
Format:	Patent
Sprache:	nor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Esters, of polar acidic metabolites of atropine, siopolamine etc. of formula (I) and having anticholinergic or mydriatic properties are new. where R' = esterification residue of a pharmaceutically acceptable, non-toxic, opt. substd. cyclic or opt.branched 1-8C alcohol (R'-OH) such that COOR1 is metabolically hydrolysable to R'-OH and a non-toxic metabolite of (I) following admin. R2 =opt. substd. aryl, cycloalkyl or alkyl of 1-8C; R3 = H or R2; n = 0-4; X = -O-CO-; -NR8-CO-, -CO-, -CR9R10-, -S-, -O- or -NH-; R8 = H or opt. branched 1-5C alkyl; R9, R10 = H or 1-5C alkyl; m = 0-4; R4 = bicyclic amine gp. formula (a), (b) or (c), -NR6R6, -NR5R6R7(+), o, m- or p-substd. alkyl pyridine, or non-toxic quat. ammonium salt gp. (-N(B)3(+)X(-)); R5, R6, R7 = 1-5C aklyl; X(-)=anion.