LAVVISKOS HOEYMOLEKYLAER FILTERSTERILISERBAR HYALURONSYRE

Processes for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solutions of hyaluronic acid and its salts (HA), especially its sodium and potassium salts, entail, to increase the average molecular weight and restrict the molecular weight distribution, th...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: TRUMP, SANDY L, BRYANT, SHARON A, GREENE, NATHAN D, BROWN, KAREN K
Format: Patent
Sprache:nor
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Processes for adjusting the average molecular weight, the molecular weight distribution and the viscosity in solutions of hyaluronic acid and its salts (HA), especially its sodium and potassium salts, entail, to increase the average molecular weight and restrict the molecular weight distribution, this material being precipitated in a bath of a nonsolvent which contains a continuously moving device to which it can adhere on precipitation. The solution viscosity of this or any other high molecular weight high viscosity HA can be reduced, with a negligible effect on its molecular weight, either by a heat treatment at moderate temperature or by passing an aqueous solution of 1% by weight or stronger through a fine-pore (1  mu m or less) filter.