Fremgangsmåte for å fremstille poly(ADP-rlbose) polymerase Inhibitorer

Fremgangsmåte for å fremstille poly(ADP-rlbose) polymerase Inhibitorer

This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.

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Bibliographische Detailangaben
Hauptverfasser: Ma, Chunrong, Nayyar, Naresh, Stankovic, Nebojsa Slobodan
Format: Patent
Sprache:nor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:This invention relates to a new and convergent route to small molecule inhibitors of poly(ADP-ribose) polymerase, such as 8-fluoro-2-{4-[(methylamino)methyl]phenyl}-1,3,4,5-tetrahydro-6H-azepino[5,4,3-cd]indol-6-one, via a key Sonogashira coupling reaction and a CuI-promoted indole formation.