Poros sfaerisk granulaer forstovningstorket blanding for komprimering til farmasoytiske tabletter og komprimerte farmasoytiske tabletter

The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets compressed from such granules. In these formul...

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Hauptverfasser: VLADYKA JR. RONALD S, KARETNY MARC S, STAMATO HOWARD J, ERKOBONI DAVID F
Format: Patent
Sprache:nor
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Beschreibung
Zusammenfassung:The present invention provides a method for preparing a spray-dried compressible granular formulation for preparing pharmaceutical tablets in which hydrolyzed cellulose is used as a granulation aid, the resulting granulations, and pharmaceutical tablets compressed from such granules. In these formulations there is employed from 1 to 97% by weight pharmaceutical active, from about 3 to 99% by weight hydrolyzed cellulose, based on the dry weight of the granulation, and optionally conventional granulation and/or tableting additives such as surfactants, disintegrants and antiadherents/flow aids.