Amider av R-2-(aminoaryl)-propionsyrer for anvendelse i forebyggingen av leukocyttaktivering

N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear...

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Hauptverfasser: BIZZARI CINZIA, COLOTTA FRANCESCO, CASELLI GIANFRANCO, CESTA MARIA CANDIDA, BERTINI RICCARDO, SABBATINI VILMA, GANDOLFI CARMELO A, ALLEGRETTI MARCELLO
Format: Patent
Sprache:nor
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Zusammenfassung:N-(2-aminoaryl-propionyl)-amides of formula (1) are described. The process for their preparation and pharmaceutical preparations thereof are also described. The amides of the invention are useful in the prevention and treatment of tissue damage due to the exacerbate recruitment of polymorphonuclear neutrophils (leukocytes PMN) at the inflammatory sites. In particular, the invention relates to the R enantiomers of 2-(aminoaryl)-propionyl amides of formula (1) for use in the ihibition of the chemotaxis of neutrophils induced by IL-8. The compounds of the invention are used in the treatment of psoriasis, ulcerative cholitis, glomerular nephritis, acute respiratory insufficiency, idiopathic fibrosis, and rheumatoid arthritis.