Fremgangsmate for forbedring av in vivo-funksjonen av rekombinant faktor VIII SQ ved a skjerme utsatte mal pa polypeptidet

The invention relates to a process for improving the in vivo function of a factor IX by shielding exposed targets of factor IX, comprising(a) immobilizing factor IX by interaction with a group-specific adsorbent carrying anionic-exchange ligands;(b) activating a biocompatible polymer;(c) conjugating...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Hauptverfasser:	AKERBLOM EVA, SANDBERG HELENA, SMEDS ANNA-LISA, DALBORG JOHANNA
Format:	Patent
Sprache:	nor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The invention relates to a process for improving the in vivo function of a factor IX by shielding exposed targets of factor IX, comprising(a) immobilizing factor IX by interaction with a group-specific adsorbent carrying anionic-exchange ligands;(b) activating a biocompatible polymer;(c) conjugating the activated biocompatible polymer to external sites of the immobilized factor IX; and(d) eluting the conjugate from the adsorbent.It relates also to conjugates of Factor IX obtained according to the above process.