Sulfonylaminoderivater som hemmer matriks-nedbrytende metalloproteinaser

Compounds of formula I wherein: W is -OH or -NHOH; X is an optionally substituted heterocycle, -NR 1 SO 2 R 2 , heterocyclylalkylthio; -CONR 2 R 3 , or-NR 1 COR 2 , Y, Z, R 1 -R 3 and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are use...

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Bibliographische Detailangaben
Hauptverfasser:	ROBINSON LESLIE ANN, KUKKOLA PAIVI JAANA, SAKAKI JUNICHI, NAKAJIMA MOTOWO
Format:	Patent
Sprache:	nor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Compounds of formula I wherein: W is -OH or -NHOH; X is an optionally substituted heterocycle, -NR 1 SO 2 R 2 , heterocyclylalkylthio; -CONR 2 R 3 , or-NR 1 COR 2 , Y, Z, R 1 -R 3 and n are as defined in the application. Compounds (I) are inhibitors of matrix-degrading metalloproteinases and are useful for the treatment of related conditions.