Lav hygroskopisk Aripiprazol medikament forbindelse og fremgangsmate for fremstilling derav

[116180]/[EH] SAMMENDRAG Foreliggende oppfinnelse tilveiebringer lav-hygroskopiske former av Aripiprazol og prosesser for fremstilling derav, som ikke omdannes til et hydrat eller taper deres opprinnelige oppløselighet selv når et medisinsk preparat inneholdende Aripiprazolanhydrid-krystallene blir...

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Hauptverfasser:	YAMADA SHOHEI, TOMINAGA MICHIAKI, TAKAHASHI MASANORI, AOKI SATOSHI, FUJIMOTO KIYOSHI, SHINHAMA KOICHI, NISHIOKA YOSHIHIRO, NAKAGAWA TOMONORI, KAWASAKI JUNICHI, TOMIKAWA KENJI, FUJIMURA TSUTOMO, ISHIGAMI MAKOTO, ABE KAORU, TANIGUCHI YOUICHI, KOBAYASHI NORIYUKI, YABUUCHI TSUYOSHI, BANDO TAKUJI, UTSUMI NAOTO, OI YOSHIHIRO
Format:	Patent
Sprache:	nor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PERFORMING OPERATIONS PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SEPARATION SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING
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Beschreibung
Zusammenfassung:	[116180]/[EH] SAMMENDRAG Foreliggende oppfinnelse tilveiebringer lav-hygroskopiske former av Aripiprazol og prosesser for fremstilling derav, som ikke omdannes til et hydrat eller taper deres opprinnelige oppløselighet selv når et medisinsk preparat inneholdende Aripiprazolanhydrid-krystallene blir lagret i en forlenget periode. 1 The present invention provides an improved low hygroscopic form, form E, of aripiprazole and processes for the preparation thereof which will not convert to a hydrate or lose their original solubility even when a medicinal preparation containing the aripiprazole anhydride crystals is stored for an extended period.