Fremgangsmate for a lage trans-1-((1R,3S)-6-klor-3-fenylindan-1-yl)-3,3-dimetylpiperazin

Fremgangsmate for a lage trans-1-((1R,3S)-6-klor-3-fenylindan-1-yl)-3,3-dimetylpiperazin

Beskrevet er en fremgangsmåte for å lage trans-1-((1R,3S)-6-klor-3-fenylindan-1-yl)-3,3-dimetylpiperazin (formel I) og salter derav og en lignende fremgangsmåte for å lage 4-((1R,3S)-6-klor-3-fenylindan-1-yl)-1,2,2-trimetylpiperazin (formel IX) og salter derav, hvilken fremgangsmåte omfatter omdanne...

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Bibliographische Detailangaben
Hauptverfasser: SUTEU CHRISTINA, NIELSEN CHRISTINA WOHLK, ROBIN DAVID, DAHL ALLAN CARSTEN, BROSEN PETER
Format: Patent
Sprache:nor
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Beskrevet er en fremgangsmåte for å lage trans-1-((1R,3S)-6-klor-3-fenylindan-1-yl)-3,3-dimetylpiperazin (formel I) og salter derav og en lignende fremgangsmåte for å lage 4-((1R,3S)-6-klor-3-fenylindan-1-yl)-1,2,2-trimetylpiperazin (formel IX) og salter derav, hvilken fremgangsmåte omfatter omdannelse av en forbindelse med formel IVa til henholdsvis forbindelsen med formel I eller forbindelsen med formel IX. Described is a method for making the trans-1-((1R,3S)-6-chloro-3-phenylin-dan-1-yl)-3,3-dimethylpiperazine (formula I) and salts thereof and a similar method for making 4-((1R,3S)-6-chloro-3-phenylin-dan-1-yl)-1,2,2-trimethylpiperazine (formula IX) and salts thereof, which method comprises conversion of a compound of formula IVa to the compound of formula I or the compound of formula IX, respectively.