Fremgangsmater til behandling av TWEAK-relaterte tilstander

S a m m e n d r a g Det er beskrevet fremgangsmåter og substanser for å behandle TWEAK-relaterte tilstander, innbefattende hjerte, lever, nyre, lunge, adipos, skjelett, muskel, nerve, ben og brusktilstander. Det er også beskrevet fremgangsmåter for å identifisere TWEAK-agonister eller antagonister t...

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Hauptverfasser:	HAHM KYUNGMIN, BURKLY LINDA, ZHENG TIMOTHY, JAKUBOWSKI ANIELA
Format:	Patent
Sprache:	nor
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	S a m m e n d r a g Det er beskrevet fremgangsmåter og substanser for å behandle TWEAK-relaterte tilstander, innbefattende hjerte, lever, nyre, lunge, adipos, skjelett, muskel, nerve, ben og brusktilstander. Det er også beskrevet fremgangsmåter for å identifisere TWEAK-agonister eller antagonister til behandling av TWEAK-relaterte tilstander. I tillegg er det beskrevet transgene dyr som uttrykker et eksogent DNA som koder for et TWEAK-polypeptid, eller fragmenter, analoger, eller muteiner derav, samt fremgangsmåter for å bruke slike dyr til å identifisere TWEAK-agonister eller antagonister. Det er videre beskrevet fremgangsmåter for å diagnostisere en sykdom basert på TWEAK-ekspresjon. Det er også beskrevet fremgangsmåter for å påvirke cellulær differensiering av progenitorceller ved å bruke TWEAK-polypeptider, agonister, eller antagonister. The present invention provides methods and agents for the treatment of TWEAK-related conditions, including cardiac, liver, kidney, lung, adipose, skeletal, muscle, neuronal, bone and cartilage conditions. The invention also provides methods for identifying TWEAK agonists or antagonists for the treatment of TWEAK-related conditions. Additionally, the invention provides transgenic animals that express an exogenous DNA encoding a TWEAK polypeptide, or fragments, analogs, or muteins thereof, and methods for using such animals to identify TWEAK agonists or antagonists. The invention further provides methods for diagnosing a disease based on TWEAK expression. The invention also provides methods for affecting cellular differentiation of progenitor cells using TWEAK polypeptides, agonists, or antagonists.