Pyrrolopyrimidin og pyrrolopyridinderivater substituert med syklisk aminogruppe

An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's ch...

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Hauptverfasser: KEYBUS FRANS MARIA ALFONS VAN DEN, ROOSBROECK YVES EMIEL MARIA VAN, BRUYN MARCEL FRANS LEOPOLD DE, YAMAGUCHI MIKAKO, OKUBO TAKETOSHI, NOZAWA DAI, HENDRICKX ROBERT JOZEF MARIA, NAKAZATO ATSURO, KENNIS LUDO EDMOND JOSEPHINE, TAMITA TOMOKO, BONGARTZ JEAN-PIERRE A M, LUYCKX MARCEL GEREBERNUS MARIA
Format: Patent
Sprache:nor
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Zusammenfassung:An object of the present invention is to provide an antagonist against CRF receptors which is effective as a therapeutic or prophylactic agent for diseases in which CRF is considered to be involved, such as depression, anxiety, Alzheimer's disease, Parkinson's disease, Huntington's chorea, eating disorder, hypertension, gastric diseases, drug dependence, epilepsy, cerebral infarction, cerebral ischemia, cerebral edema, cephalic external wound, inflammation, immunity-related diseases, alopecia, irritable bowel syndrome, sleep disorders, epilepsy, dermatitides, schizophrenia, etc. [SOLUTION] A pyrrolopyrimidine or pyrrolopyridine derivative substituted with a cyclic amino group represented by the following formula [I]: has a high affinity for CRF receptors and is effective against diseases in which CRF is considered to be involved.