Kjemokinreseptor-bindende heterosykliske forbindelser med forsterket effektivitet

The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings....

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	NAN SIQIAO, SCHOLS DOMENIQUE, CRAWFORD JASON, SMITH CHRISTOPHER DENNIS, KALLER AL, ZHOU YUANXI, HARWIG CURTIS, SKERLJ RENATO T, BIDGER GARY J, BOGUCKI DAVID, MCEACHERN ERNEST J, FLURI MARIA ROSARIA DI, WILSON TREVOR R, ATSMA BERN
Format:	Patent
Sprache:	nor
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The invention relates to heterocyclic compounds consisting of a core nitrogen atom surrounded by three pendant groups, wherein two of the three pendant groups are preferably benzimidazolyl methyl and tetrahydroquinolyl, and the third pendant group contains N and optionally contains additional rings. The compounds bind to chemokine receptors, including CXCR4 and CCR5, and demonstrate protective effects against infection of target cells by a human immunodeficiency virus (HIV).