Inhibitorer for legemiddelfjerningspumpe

Legemidler for forhindring og/eller. behandling av mikrobielle infeksjons-sykdommer, som inneholder som den. aktive bestanddel forbindelser som har. formel (I) :. fysiologisk akseptable salter derav eller hydrater av de samme, og som har en virkning ved at de gjør en mikro-organisme med ervervet toleranse for et legemiddel ikke-tolerant. I formelen erog R2 uavhengig av hverandre hydro-gen, halogen, karboksy etc;er heteroaryl med 5 eller 6 medlemmer; Wer -CH=CH-, -CHsCH-, -CHCH- etc; A. er fenylen, pyridindiyl, furandiyl etc; Ger oksygen, karbonyl, etynyl. etc; p er et helt tall fra 0 til 3; Ger fenylen, furandiyl, tetrahydrofuran-diyl etc; Ger -CH- eller en enkelt-binding; m og n er hver et helt tall på 0 eller 1; og Qer en sur gruppe. A medicament for preventive and/or therapeutic treatment of a microbial infection having an activity of eliminating resistance of a microorganism with acquired resistance to an antimicrobial agent, which comprises as an active ingredient a compound represented by the following general formula (I), a physiologically acceptable salt thereof, or a hydrate thereof: wherein R 1 and R 2 independently represent hydrogen atom, a halogen atom, carboxyl group and the like; J 1 represents a 5- or 6-membered heteroaromatic ring; W 1 represents -CH=CH-, -C‰¡C-, -CH 2 CH 2 - and the like; A 1 represents phenylene group, pyridinediyl group, furandiyl group and the like; G 1 represents oxygen atom, carbonyl group, ethynyl group and the like; p represents an integer of from 0 to 3; G 2 represents phenylene group, furandiyl group, tetrahydrofurandiyl group and the like; G 3 represents -CH 2 - or single bond; m and n represent an integer of 0 or 1; and Q 1 represents an acidic group.