Pyrimidinforbindelser

Pyrimidinforbindelser

A pyrimidine derivative of formula (I) or (I'): wherein: R is a substituent as defined within; Q1 is optionally substituted phenyl, and Q1 bears a substituent of formula (Ia) wherein: X, Y , Y , Z, n, and m are as defined within; -NQ2 is an optionally substituted heterocyclic moiety containing...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: BREAULT, GLORIA ANNE, JAMES, STEWART RUSSELL, PEASE, JANET ELIZABETH
Format: Patent
Sprache:nor
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:A pyrimidine derivative of formula (I) or (I'): wherein: R is a substituent as defined within; Q1 is optionally substituted phenyl, and Q1 bears a substituent of formula (Ia) wherein: X, Y , Y , Z, n, and m are as defined within; -NQ2 is an optionally substituted heterocyclic moiety containing one hydrogen heteroatom and optionally containing a further heteroatom; or a pharmaceutically acceptable salt in vivo hydrolysable ester thereof; are useful as anti-cancer agents. Processes for their manufacture and pharmaceutical compositions containing them are described.