Terapeutiske anvendelser av modne flint (mFLINT) polypeptider eller OPG3, et medlem av TNF reseptor superfamilien

Moden FLINT protein (mFLINT) binder FasL og LIGHT, og hindrer FasL-Fas interaksjon. mFLINT inhiberer FasL-Fas-fbrmidlet apoptotisk og proinflammatorisk aktivitet, og er nyttig i å behandle sykdommer assosiert med unormal apoptose inflammasjon. Oppfinnelsen tilveiebringer aminosyre og nukleotidsekven...

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Hauptverfasser:	HEUER, JOSEF GEORG, KHARITONENKOV, ALEXEI, REIDY, CHARLES ARTHUR, GOULD, KENNETH ELLIOT, MIZRAHI, JACQUES, WU, XIYING, NA, SONGQING, ZUCKERMAN, STEVEN HAROLD, DOU, SHENSHEN, HALE, JOHN EDWARD, HUI, KWAN YUK, GLASEBROOK, ANDREW LAWRENCE, SONG, HO YEONG, NOBLITT, TIMOTHY WAYNE, WANG, JIAN, BUMOL, THOMAS FRANK
Format:	Patent
Sprache:	nor
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY CARE OF BIRDS, FISHES, INSECTS CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NEW BREEDS OF ANIMALS ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Moden FLINT protein (mFLINT) binder FasL og LIGHT, og hindrer FasL-Fas interaksjon. mFLINT inhiberer FasL-Fas-fbrmidlet apoptotisk og proinflammatorisk aktivitet, og er nyttig i å behandle sykdommer assosiert med unormal apoptose inflammasjon. Oppfinnelsen tilveiebringer aminosyre og nukleotidsekvenser av FLINT og modent FLINT. Fremstillingen og karakteriseringen av transgene dyr som uttrykker FLINT er beskrevet. Terapeutiske sammensetninger og metoder for behandling som benytter mFLINT er også tilveiebrakt. Mature FLINT protein (mFLINT) binds FasL and LIGHT, and prevents FasL-Fas interaction. mFLINT inhibits FasL-Fas-mediated apoptotic and proinflammatory activity, and is useful in treating disorders associated with abnormal apoptosis and inflammation. The invention provides the amino acid and nucleotide sequences of FLINT and mature FLINT. The preparation and characterization of transgenic animals that express FLINT is disclosed. Therapeutic compositions and methods of treatment utilizing mFLINT also are provided.