Monoklonale antistoffer som binder testosteron

Den foreliggende oppfinnelse tilveiebringer monoklonale antistoffer og derivater derav egnet for anvendelse i immunodiagnostisk analyse av testosteron. Spesielt, er slike reagenser beskre-vet som har affinitet for testosteron på minst omtrent 10M'og utviser mindre enn 0,05% kryssreaktivitet med...

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Bibliographische Detailangaben
Hauptverfasser:	TAKKINEN, KRISTIINA, SOEDERLUND, HANS, HEMMINKI, ARI, NIEMI, SEIJA
Format:	Patent
Sprache:	nor
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PHYSICS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TESTING VINEGAR WINE
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Beschreibung
Zusammenfassung:	Den foreliggende oppfinnelse tilveiebringer monoklonale antistoffer og derivater derav egnet for anvendelse i immunodiagnostisk analyse av testosteron. Spesielt, er slike reagenser beskre-vet som har affinitet for testosteron på minst omtrent 10M'og utviser mindre enn 0,05% kryssreaktivitet med dehydroepiandrosteronsulfat (DHEAS), mindre enn 10% kryssreaktivitet med 5a-dihydrotestosteron (5a-DHT) og mindre enn 5% kryssreaktivitet med androstendion bestemt på basis av ED-verdier. The present invention provides monoclonal antibodies and derivatives thereof suitable for use in immunodiagnostic assay of testosterone. In particular, such reagents are disclosed having affinity for testosterone of at least about 10 M and exhibiting less than 0.05 % cross-reactivity with dehydroepiandrosterone sulphate (DHEAS), less than 10 % cross-reactivity with 5 alpha -dihydrotestosterone (5 alpha -DHT) and less than 5 % cross-reactivity with androstenedione determined on the basis of ED50 values.