8-substituerte-9H-1,3-Dioxolo/4,5- h//2,3/benzodiazepinderivater, som AMPA/KAINAT reseptorinhibitorer

8-substituerte-9H-1,3-Dioxolo/4,5- h//2,3/benzodiazepinderivater, som AMPA/KAINAT reseptorinhibitorer

The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benz...

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Bibliographische Detailangaben
Hauptverfasser: SZABO, GEZA, CSELENYOK, JUDIT, SIMIG, GYULA, SZABADOS, TAMSS, GREFF, ZOLTSN, SIMO, ANNAMSRIA, NAGY, PETER KOTAY, SERES, PETER, LEVAY, GYOERGY, KOVSCS, ATTILA, TIHANYI, KSROLY, RSTKAI, ZOLTSN, GACSSLYI, ISTVSN, GYERTYSN, ISTVSN, DOMSN, IMRE, SCHNEIDER, GEZA, GIGLER, GSBOR, VEGH, MIKLOS, BARKOCZY, JOZSEF, BALSZS, LSSZLO, EGYED, ANDRSS
Format: Patent
Sprache:nor
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Zusammenfassung:The disclosure relates to a novel 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound of formula I and pharmaceutically acceptable quaternary ammonium salts thereof, a process for preparing the same, a pharmaceutical composition containing a 8-substituted-9H-1,3-dioxolo-[4,5-h][2,3]benzodiazepine compound, and a method of treatment using the pharmaceutical composition. A complete description of the compound of formula I is found in the specification. The compounds of the general formula I possess unique competitive AMPA/kainite antagonist properties making them useful in the treatment of diseases where inhibition of the AMPA/kainite receptors may a favorable effect.