MELLOMPRODUKT

Det er beskrevet et mellomprodukt med formelen. hvor n er 1, 2 eller 3 og X er hydrogen, Ci-C-alkyl,. Ci-C-alkoksy, halogen, hydroksy, nitro, trifluormetyl,. NHC0Rhvor Rer C-C-alkyl, eller NRRhvor Rog Ruavhengig av hverandre er hydrogen eller C-C-alkyl.Mellomproduktet er spesielt' egnet for fre...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: PIERRAT, FRANK A, SHUTSKE, GREGORY M
Format: Patent
Sprache:nor
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Det er beskrevet et mellomprodukt med formelen. hvor n er 1, 2 eller 3 og X er hydrogen, Ci-C-alkyl,. Ci-C-alkoksy, halogen, hydroksy, nitro, trifluormetyl,. NHC0Rhvor Rer C-C-alkyl, eller NRRhvor Rog Ruavhengig av hverandre er hydrogen eller C-C-alkyl.Mellomproduktet er spesielt' egnet for fremstilling av 9-amlno-l,2,3,4-tetrahydroakridin-l-oler og beslektede forbindelser. There are disclosed compounds having the formula for wherein n is 1, 2 or 3; X is hydrogen, loweralkyl, loweralkoxy, halogen, hydroxy, nitro, trifluoromethyl, NHCOR2 where R2 is loweralkyl, or NR3R4 where R3 and R4 are independently hydrogen or loweralkyl; R is hydrogen or loweralkyl; R1 is hydrogen, loweralkyl, diloweralkylaminoloweralkyl, arylloweralkyl, diarylloweralkyl, furylloweralkyl, thienylloweralkyl, oxygen-bridged arylloweralkyl, oxygen-bridged diarylloweralkyl, oxygen-bridged furylloweralkyl or oxygen-bridged thienylloweralkyl; Y is C=O or CR5OH where R5 is hydrogen or loweralkyl; Z is CH2 or C=CR6R7 where R6 and R7 are independently hydrogen or loweralkyl; or Y and Z taken together is CR5=CH where CR5 and CH correspond to Y and Z respectively; an optical antipode thereof, or a pharmaceutically acceptable acid addition salt thereof, which are useful for enhancing memory, methods for synthesizing them, and pharmaceutical compositions comprising an effective memory enhancing amount of such a compound.