FREMGANGSMAATE VED FREMSTILLING AV ET TERAPEUTISK AKTIVT (6R,7R)-3-KARBAMOYLOKSYMETYL-7-((Z)-2-(FUR-2-YL)-2-METOKSYIMINOACETAMIDO)-CEPH-3-EM-4-KARBOKSYLSYRE-1-ACETOKSYETYLESTER (CEFUROKSIMAKSETIL)

FREMGANGSMAATE VED FREMSTILLING AV ET TERAPEUTISK AKTIVT (6R,7R)-3-KARBAMOYLOKSYMETYL-7-((Z)-2-(FUR-2-YL)-2-METOKSYIMINOACETAMIDO)-CEPH-3-EM-4-KARBOKSYLSYRE-1-ACETOKSYETYLESTER (CEFUROKSIMAKSETIL)

There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administra...

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Bibliographische Detailangaben
Hauptverfasser: CRISP, HAROLD ALFRED, CLAYTON, JOHN CHARLES, ELLIOTT, LEONARD GODFREY, WILSON, EDWARD MCKENZIE
Format: Patent
Sprache:nor
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:There is described a product which is a highly pure substantially amorphous form of cefuroxime axetil (cefuroxime 1-acetoxyethyl ester) which is stable, which has increased absorption via the gastro-intestinal tract and has a correspondingly high level of bioavailability on oral or rectal administration.Methods of preparing the product are also described which involve the recovery of the product from a solution thereof. A preferred method is the use of spray drying techniques, though roller drying, solvent precipitation or freeze-drying are also described.Also disclosed are pharmaceutical compositions containing the product and methods for its use in medicine.