ANALOGIFREMGANGSMAATE TIL FREMSTILLING AV TERAPEUTISK VIRKSOMME 1-FENYLINDAZOL-3-ON-FORBINDELSER OG DERES SALTER

Compounds corresponding to the formula: II wherein R1 and R3 each represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R2 and R4 each represent hydrogen, halogen, lower alkyl or lower alkoxy; Z represents an alkylene radical with 2 to 6 carbon atoms and Y'' is halogen...

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Hauptverfasser: HEINEMANN, HENNING, ZEUGNER, HORST, JASSERAND, DANIEL, YAVORDIOS, DIMITRI, MILKOWSKI, WOLFGANG
Format: Patent
Sprache:nor
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Zusammenfassung:Compounds corresponding to the formula: II wherein R1 and R3 each represent hydrogen, halogen, lower alkyl, lower alkoxy or trifluoromethyl; R2 and R4 each represent hydrogen, halogen, lower alkyl or lower alkoxy; Z represents an alkylene radical with 2 to 6 carbon atoms and Y'' is halogen, hydroxyl, lower alkanesulphonyl, benzenesulphonyl, or lower alkyl or halogen substituted benzenesulphonyl, and acid addition salts thereof, with the proviso the Y'' is other than chlorine if R1, R2, R3 and R4 each are hydrogen and Z is ethylene or propylene. The claimed compounds are useful intermediates in the synthesis of 1-phenyl-2-[(4-substituted piperazinyl) alkyl]-1,2-dihydro-3H-indazol-3-ones which exhibit antiallergic activity.