ANALOGIFREMGANGSMAATE FOR FREMSTILLING AV TERAPEUTISK AKTIVE HOMOCYKLISKE DERIVATER

Aphidicolane derivatives of the formula: wherein R1 stands for hydrogen or a hydroxy radical, R2 stands for a hydroxy or methyl radical, or the group CR1R2 stands for a keto group; R3 stands for a formyl or hydroxymethyl radical, or for the group -CH2O.CO.OR6, wherein R6 stands for a defined radical...

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Bibliographische Detailangaben
1. Verfasser:	RATCLIFFE, ARNOLD HARRY
Format:	Patent
Sprache:	nor
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Aphidicolane derivatives of the formula: wherein R1 stands for hydrogen or a hydroxy radical, R2 stands for a hydroxy or methyl radical, or the group CR1R2 stands for a keto group; R3 stands for a formyl or hydroxymethyl radical, or for the group -CH2O.CO.OR6, wherein R6 stands for a defined radical or R2 and R3 are joined together to form the group -O.CO.OCH2-; R4 stands for a hydroxy radical; R5 stands for a formyl radical, a hydroxyalkyl radical -(CH2)1-3OH, a radical -CHR7OH, wherein R7 stands for a defined radical, or R5 stands for an azidomethyl or pyrrolidinylcarbonyloxymethyl radical, or for the group -CH2O.CO.OR8, wherein R8 stands for a defined radical, or R5 stands for the group -CH2O.CO.(CH2)m.CR11R12.(CH2)n.NR9R10, wherein m, n, R9, R10, R11 and R12 have defined values, or R5 stands for the group -CH2O.SO2.R13, wherein R13 stands for a defined radical; or R4 and R5 are joined together to form the group -O.CH2- or -O.CO.OCH2-; and, where appropriate, pharmaceutically-acceptable salts thereof. Processes for the preparation of said aphidicolane derivatives. Pharmaceutical compositions comprising one of the compounds and a pharmaceutical diluent or carrier. The compounds exhibit inhibitory activity against DNA-containing viruses and they inhibit the growth of some tumors.