FREMGANGSMAATE TIL FREMSTILLING AV 1-HYDROKSY-2-PYRIDONER

1416397 Process for 1-hydroxy-2-pyridones HOECHST AG 21 March 1973 [25 March 1972] 13587/73 Heading C2C The invention comprises making compounds in which R 1 represents an alkyl radical of 1 to 17 carbon atoms which may be branched; an alkenyl radical of 2 to 17 carbon atoms; a cycloalkyl radical of 3 to 8 carbon atoms; a cyclohexylalkyl radical; a phenyl, phenylalkyl, phenylalkenyl, benzhydryl, phenoxymethyl; phenylmercaptomethyl or phenyl-sulphonylmethyl radical which may be substituted in the aromatic nucleus by one or more alkyl, alkoxy, amino, nitro, alkoxycarbonyl or cyano groups or halogen atoms; or a furyl or furylalkenyl radical; R 2 represents a hydrogen atom or an alkyl, alkenyl or alkynyl radical or a benzyl group or R 2 together with R 1 or R 3 forms a 5- or 6- membered carbocyclic ring; R 3 represents a hydrogen atom, an alkyl radical or a phenyl group and R 4 represents a hydrogen atom, an alkyl or alkenyl radical, a methoxymethyl or benzyl radical, or a chlorine or bromine atom, by reacting a 2-pyrone of the general Formula (II) with NH 2 OH or its salt in the presence of an optionally substituted aminopyridine or imidazole. Pharmaceutical preparations showing antibacterial and antimycotic actions contain (I) as active ingredient.