NO131031B

1309948 Benzodiazepines SUMITOMO CHEMICAL CO Ltd 19 April 1971 [3 Feb 1970 5 Feb 1970 24 June 1970 (2)] 20827/71 Heading C2C Compounds of the general formula (R 1 =H, halogen, NO 2 , CN, CF 3 , C 1-4 alkoxy; R 2 =Py, R 5 R 6 Ph; R 5,6 =H, halogen, CF 3 , Me, Et; R 3 =H, C 1-4 alkyl; R 4 =C 1-4 alkyl...

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Hauptverfasser:	KUME Y,JA, YAMAMOTO M,JA, ISHIZUMI K,JA, INABA S,JA, IZUMI T,JA, AKATSU M,JA, YAMAMOTO H,JA, HIROHASHI T,JA, MORI K,JA, MARUYAMA I,JA
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	1309948 Benzodiazepines SUMITOMO CHEMICAL CO Ltd 19 April 1971 [3 Feb 1970 5 Feb 1970 24 June 1970 (2)] 20827/71 Heading C2C Compounds of the general formula (R 1 =H, halogen, NO 2 , CN, CF 3 , C 1-4 alkoxy; R 2 =Py, R 5 R 6 Ph; R 5,6 =H, halogen, CF 3 , Me, Et; R 3 =H, C 1-4 alkyl; R 4 =C 1-4 alkyl, C 3-6 cycloalkyl, C 3-6 cycloalkyl-C 1-4 alkyl, aryl, aralkyl; m=1, 2; n=1-4) and their salts are preparedby (a) introduction of the 1-substituent, (b) oxidizing the corresponding compound in which m=0 or 1, n=2 or 3 and R 2 is not Py, (c) indole ring-expansion, (d) reacting a compound of the formula with a compound of the formula or (e) removing Z from a compound of the formula (n1 = 2, 3; Z = nitrogen protecting system), optionally followed in each case by salt formation. The above compounds are tranquillizers, sedatives, muscle relaxants, spasmolytics and hypnotics, and may be administered in the form of pharmaceutical preparations containing them in association with a carrier. Reference has been directed by the Comptroller to Specification 972,968.