BROAD-SPECTRUM MRNA VACCINE AGAINST BOVINE VIRAL DIARRHEA VIRUS AND USE THEREOF

The present invention relates to a broad-spectrum mRNA vaccine against bovine viral diarrhea virus (BVDV), and a preparation method and use thereof. The present invention 5 speciﬁcally provides a trivalent BVDV mRNA against the strains of a variety of genotypes of BVDV, which includes sequentially,...

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Bibliographische Detailangaben
Hauptverfasser:	TIYUN HAN, CAIYI FEI, SHI XU
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to a broad-spectrum mRNA vaccine against bovine viral diarrhea virus (BVDV), and a preparation method and use thereof. The present invention 5 speciﬁcally provides a trivalent BVDV mRNA against the strains of a variety of genotypes of BVDV, which includes sequentially, from the N end to the C end, a bovine IgGl secretion signal peptide, a bovine IgGl Fc fragment, BVDVla E2 protein domains I-II, BVDVlb E2 protein domains 1-H, and BVDV2 E2 protein domains I-II. According to the present invention, the antigens of different genotypes of BVDV are simultaneously eXpressed by using a strand 10 of mRNA that has strong immunogenicity, is effectively secreted at a high level in the animals, to induce the production of higher-level speciﬁc neutralizing antibody against BVDVla, BVDVlb and BVDV 2, and produces desirable immune efﬁcacy against the strains of a variety of genotypes of BVDV.