DNA Gyrase Inhibitors

DNA Gyrase Inhibitors

Provided are compounds useful fortreating bacterial infections, e.g. Gram-negative bacterial infection. The compounds may be of formula I as defined herein: R4 R1 R2 O | RBa 0%ll/N\)\ ( % R7 S N H X1 \ R5 || X2 / \X3 ( R6 )n . 5 The compounds may be capable of binding a horseshoe-like hydrophobic po...

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Bibliographische Detailangaben
Hauptverfasser: RICHARD J.H.B.N VAN DEN BERG, IOLI KOTSOGIANNI, NATHANIEL I. MARTIN, JEROEN M. PUNT, MARIANA AVALOS, GILLES P. VAN WEZEL, ALEXANDER T. BAKKER, CONSTANT A.A. VAN BOECKEL, DMITRY GHILAROV, DIANA PIERMARINI, MARIO VAN DER STELT, BING LIU
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided are compounds useful fortreating bacterial infections, e.g. Gram-negative bacterial infection. The compounds may be of formula I as defined herein: R4 R1 R2 O | RBa 0%ll/N\)\ ( % R7 S N H X1 \ R5 || X2 / \X3 ( R6 )n . 5 The compounds may be capable of binding a horseshoe-like hydrophobic pocket on the DNA-binding surface GyrA subunit of DNA gyrase. Also provided are formulations comprising such compounds, as well uses of such compounds or formulations, e.g. forthe treatment of bacterial infection, and/or as a DNA gyrase inhibitor.