COMPOSITIONS COMPRISING HYDROXYETHYL-CAPPED CATIONIC PEPTOIDS

The present disclosure provides delivery vehicle compositions comprising hydroxyethyl- capped tertiary amino lipidated cationic peptoids, and complexes of the delivery vehicles with polyanionic compounds, such as nucleic acids. The disclosure further provides methods of making and using the delivery...

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1. Verfasser: COLIN MCKINLAY
Format: Patent
Sprache:eng
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Zusammenfassung:The present disclosure provides delivery vehicle compositions comprising hydroxyethyl- capped tertiary amino lipidated cationic peptoids, and complexes of the delivery vehicles with polyanionic compounds, such as nucleic acids. The disclosure further provides methods of making and using the delivery vehicle compositions and complexes, such as for the delivery polyanionic compounds (e. g., nucleic acids) to cells. The disclosure also provides methods of eliciting an immune response With the delivery vehicle complexes of the disclosure.